Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.
Identifieur interne : 001910 ( Main/Exploration ); précédent : 001909; suivant : 001911Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.
Auteurs : Rudolf M. Gruber [Allemagne] ; Sebastian Krohn ; Corinna Mauth ; Michel Dard ; Aart Molenberg ; Katharina Lange ; Christina Perske ; Henning SchliephakeSource :
- Journal of clinical periodontology [ 1600-051X ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Attribution aléatoire, Densité osseuse (), Facteur de croissance transformant bêta (usage thérapeutique), Femelle, Maladies mandibulaires (), Mandibule (), Mandibule (anatomopathologie), Matériaux biocompatibles (usage thérapeutique), Mâchoire partiellement édentée (), Ostéogenèse (), Phosphates de calcium (usage thérapeutique), Porc miniature, Processus alvéolaire (), Processus alvéolaire (anatomopathologie), Protéine morphogénétique osseuse de type 2 (usage thérapeutique), Protéines recombinantes (usage thérapeutique), Reconstruction mandibulaire (), Résorption alvéolaire (), Substituts osseux (usage thérapeutique), Suidae, Vecteurs de médicaments.
- MESH :
- anatomopathologie : Mandibule, Processus alvéolaire.
- usage thérapeutique : Facteur de croissance transformant bêta, Matériaux biocompatibles, Phosphates de calcium, Protéine morphogénétique osseuse de type 2, Protéines recombinantes, Substituts osseux.
- Animaux, Attribution aléatoire, Densité osseuse, Femelle, Maladies mandibulaires, Mandibule, Mâchoire partiellement édentée, Ostéogenèse, Porc miniature, Processus alvéolaire, Reconstruction mandibulaire, Résorption alvéolaire, Suidae, Vecteurs de médicaments.
English descriptors
- KwdEn :
- Alveolar Bone Loss (surgery), Alveolar Process (drug effects), Alveolar Process (pathology), Animals, Biocompatible Materials (therapeutic use), Bone Density (drug effects), Bone Morphogenetic Protein 2 (therapeutic use), Bone Substitutes (therapeutic use), Calcium Phosphates (therapeutic use), Drug Carriers, Female, Hydrogel, Polyethylene Glycol Dimethacrylate (therapeutic use), Jaw, Edentulous, Partially (surgery), Mandible (drug effects), Mandible (pathology), Mandibular Diseases (surgery), Mandibular Reconstruction (methods), Osteogenesis (drug effects), Random Allocation, Recombinant Proteins (therapeutic use), Swine, Swine, Miniature, Transforming Growth Factor beta (therapeutic use).
- MESH :
- chemical , therapeutic use : Biocompatible Materials, Bone Morphogenetic Protein 2, Bone Substitutes, Calcium Phosphates, Hydrogel, Polyethylene Glycol Dimethacrylate, Recombinant Proteins, Transforming Growth Factor beta.
- drug effects : Alveolar Process, Bone Density, Mandible, Osteogenesis.
- methods : Mandibular Reconstruction.
- pathology : Alveolar Process, Mandible.
- surgery : Alveolar Bone Loss, Jaw, Edentulous, Partially, Mandibular Diseases.
- Animals, Drug Carriers, Female, Random Allocation, Swine, Swine, Miniature.
Abstract
To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone.
DOI: 10.1111/jcpe.12264
PubMed: 24738890
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Bone Loss (surgery)</term>
<term>Alveolar Process (drug effects)</term>
<term>Alveolar Process (pathology)</term>
<term>Animals</term>
<term>Biocompatible Materials (therapeutic use)</term>
<term>Bone Density (drug effects)</term>
<term>Bone Morphogenetic Protein 2 (therapeutic use)</term>
<term>Bone Substitutes (therapeutic use)</term>
<term>Calcium Phosphates (therapeutic use)</term>
<term>Drug Carriers</term>
<term>Female</term>
<term>Hydrogel, Polyethylene Glycol Dimethacrylate (therapeutic use)</term>
<term>Jaw, Edentulous, Partially (surgery)</term>
<term>Mandible (drug effects)</term>
<term>Mandible (pathology)</term>
<term>Mandibular Diseases (surgery)</term>
<term>Mandibular Reconstruction (methods)</term>
<term>Osteogenesis (drug effects)</term>
<term>Random Allocation</term>
<term>Recombinant Proteins (therapeutic use)</term>
<term>Swine</term>
<term>Swine, Miniature</term>
<term>Transforming Growth Factor beta (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Attribution aléatoire</term>
<term>Densité osseuse ()</term>
<term>Facteur de croissance transformant bêta (usage thérapeutique)</term>
<term>Femelle</term>
<term>Maladies mandibulaires ()</term>
<term>Mandibule ()</term>
<term>Mandibule (anatomopathologie)</term>
<term>Matériaux biocompatibles (usage thérapeutique)</term>
<term>Mâchoire partiellement édentée ()</term>
<term>Ostéogenèse ()</term>
<term>Phosphates de calcium (usage thérapeutique)</term>
<term>Porc miniature</term>
<term>Processus alvéolaire ()</term>
<term>Processus alvéolaire (anatomopathologie)</term>
<term>Protéine morphogénétique osseuse de type 2 (usage thérapeutique)</term>
<term>Protéines recombinantes (usage thérapeutique)</term>
<term>Reconstruction mandibulaire ()</term>
<term>Résorption alvéolaire ()</term>
<term>Substituts osseux (usage thérapeutique)</term>
<term>Suidae</term>
<term>Vecteurs de médicaments</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Biocompatible Materials</term>
<term>Bone Morphogenetic Protein 2</term>
<term>Bone Substitutes</term>
<term>Calcium Phosphates</term>
<term>Hydrogel, Polyethylene Glycol Dimethacrylate</term>
<term>Recombinant Proteins</term>
<term>Transforming Growth Factor beta</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mandibule</term>
<term>Processus alvéolaire</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Alveolar Process</term>
<term>Bone Density</term>
<term>Mandible</term>
<term>Osteogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mandibular Reconstruction</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alveolar Process</term>
<term>Mandible</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Alveolar Bone Loss</term>
<term>Jaw, Edentulous, Partially</term>
<term>Mandibular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Facteur de croissance transformant bêta</term>
<term>Matériaux biocompatibles</term>
<term>Phosphates de calcium</term>
<term>Protéine morphogénétique osseuse de type 2</term>
<term>Protéines recombinantes</term>
<term>Substituts osseux</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Drug Carriers</term>
<term>Female</term>
<term>Random Allocation</term>
<term>Swine</term>
<term>Swine, Miniature</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Attribution aléatoire</term>
<term>Densité osseuse</term>
<term>Femelle</term>
<term>Maladies mandibulaires</term>
<term>Mandibule</term>
<term>Mâchoire partiellement édentée</term>
<term>Ostéogenèse</term>
<term>Porc miniature</term>
<term>Processus alvéolaire</term>
<term>Reconstruction mandibulaire</term>
<term>Résorption alvéolaire</term>
<term>Suidae</term>
<term>Vecteurs de médicaments</term>
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<front><div type="abstract" xml:lang="en">To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone.</div>
</front>
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<affiliations><list><country><li>Allemagne</li>
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<tree><noCountry><name sortKey="Dard, Michel" sort="Dard, Michel" uniqKey="Dard M" first="Michel" last="Dard">Michel Dard</name>
<name sortKey="Krohn, Sebastian" sort="Krohn, Sebastian" uniqKey="Krohn S" first="Sebastian" last="Krohn">Sebastian Krohn</name>
<name sortKey="Lange, Katharina" sort="Lange, Katharina" uniqKey="Lange K" first="Katharina" last="Lange">Katharina Lange</name>
<name sortKey="Mauth, Corinna" sort="Mauth, Corinna" uniqKey="Mauth C" first="Corinna" last="Mauth">Corinna Mauth</name>
<name sortKey="Molenberg, Aart" sort="Molenberg, Aart" uniqKey="Molenberg A" first="Aart" last="Molenberg">Aart Molenberg</name>
<name sortKey="Perske, Christina" sort="Perske, Christina" uniqKey="Perske C" first="Christina" last="Perske">Christina Perske</name>
<name sortKey="Schliephake, Henning" sort="Schliephake, Henning" uniqKey="Schliephake H" first="Henning" last="Schliephake">Henning Schliephake</name>
</noCountry>
<country name="Allemagne"><noRegion><name sortKey="Gruber, Rudolf M" sort="Gruber, Rudolf M" uniqKey="Gruber R" first="Rudolf M" last="Gruber">Rudolf M. Gruber</name>
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