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Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.

Identifieur interne : 001910 ( Main/Exploration ); précédent : 001909; suivant : 001911

Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2.

Auteurs : Rudolf M. Gruber [Allemagne] ; Sebastian Krohn ; Corinna Mauth ; Michel Dard ; Aart Molenberg ; Katharina Lange ; Christina Perske ; Henning Schliephake

Source :

RBID : pubmed:24738890

Descripteurs français

English descriptors

Abstract

To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone.

DOI: 10.1111/jcpe.12264
PubMed: 24738890


Affiliations:


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Le document en format XML

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<nlm:affiliation>Department of Oral and Maxillofacial Surgery, Georgia Augusta University, Goettingen, Germany.</nlm:affiliation>
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<term>Alveolar Bone Loss (surgery)</term>
<term>Alveolar Process (drug effects)</term>
<term>Alveolar Process (pathology)</term>
<term>Animals</term>
<term>Biocompatible Materials (therapeutic use)</term>
<term>Bone Density (drug effects)</term>
<term>Bone Morphogenetic Protein 2 (therapeutic use)</term>
<term>Bone Substitutes (therapeutic use)</term>
<term>Calcium Phosphates (therapeutic use)</term>
<term>Drug Carriers</term>
<term>Female</term>
<term>Hydrogel, Polyethylene Glycol Dimethacrylate (therapeutic use)</term>
<term>Jaw, Edentulous, Partially (surgery)</term>
<term>Mandible (drug effects)</term>
<term>Mandible (pathology)</term>
<term>Mandibular Diseases (surgery)</term>
<term>Mandibular Reconstruction (methods)</term>
<term>Osteogenesis (drug effects)</term>
<term>Random Allocation</term>
<term>Recombinant Proteins (therapeutic use)</term>
<term>Swine</term>
<term>Swine, Miniature</term>
<term>Transforming Growth Factor beta (therapeutic use)</term>
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<term>Animaux</term>
<term>Attribution aléatoire</term>
<term>Densité osseuse ()</term>
<term>Facteur de croissance transformant bêta (usage thérapeutique)</term>
<term>Femelle</term>
<term>Maladies mandibulaires ()</term>
<term>Mandibule ()</term>
<term>Mandibule (anatomopathologie)</term>
<term>Matériaux biocompatibles (usage thérapeutique)</term>
<term>Mâchoire partiellement édentée ()</term>
<term>Ostéogenèse ()</term>
<term>Phosphates de calcium (usage thérapeutique)</term>
<term>Porc miniature</term>
<term>Processus alvéolaire ()</term>
<term>Processus alvéolaire (anatomopathologie)</term>
<term>Protéine morphogénétique osseuse de type 2 (usage thérapeutique)</term>
<term>Protéines recombinantes (usage thérapeutique)</term>
<term>Reconstruction mandibulaire ()</term>
<term>Résorption alvéolaire ()</term>
<term>Substituts osseux (usage thérapeutique)</term>
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<term>Hydrogel, Polyethylene Glycol Dimethacrylate</term>
<term>Recombinant Proteins</term>
<term>Transforming Growth Factor beta</term>
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<term>Processus alvéolaire</term>
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<term>Alveolar Process</term>
<term>Bone Density</term>
<term>Mandible</term>
<term>Osteogenesis</term>
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<term>Mandibular Reconstruction</term>
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<term>Alveolar Process</term>
<term>Mandible</term>
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<term>Protéine morphogénétique osseuse de type 2</term>
<term>Protéines recombinantes</term>
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<term>Random Allocation</term>
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<term>Attribution aléatoire</term>
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<term>Processus alvéolaire</term>
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<front>
<div type="abstract" xml:lang="en">To test the hypothesis that a synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) construct combined with polyethylene glycol (PEG) hydrogel including recombinant human bone morphogenetic proteins-2 (rhBMP-2) enhances new bone formation compared with bone morphogenetic proteins-2 (BMP-2) delivered using the HA/TCP construct alone.</div>
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